Targeting GOF Mutations in Leukemia: FLT3 and NOTCH1

Understanding GOF mutations is crucial for developing targeted therapies which inhibit the activity of aberrant proteins. Here, we explored FLT3 and NOTCH1 as GOF mutations associated with leukemia disease progression.

Written by
Anna Tzani
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  • Target Selection
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GOF Mutations and Targeted Therapy

Leukemia: A Blood and Bone Marrow Cancer

Targeting GOF Mutations in Leukemia

Targeting GOF Mutations in Leukemia: FLT3 and NOTCH1 image 0
Figure 1. GOF mutations associated with leukemia disease progression.

Targeting FLT3 in Leukemia

Targeting NOTCH1 in Leukemia

Conclusion

References

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