Drug Discovery

Target-Based Drug Discovery Begins with Understanding Disease Pathophysiology

Target-based drug discovery begins with understanding the physiological basis of the disease, and the subsequent abnormal or deviant pathways and targets responsible for the disease phenotype.¹ A foundational understanding of disease pathophysiology therefore serves as a roadmap for drug development success.

Written by
Elizabeth Bolitho
  • Categories
  • Disease Pathophysiology
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Disease Pathophysiology: A Roadmap to Success

Disease Biology is Complex

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Identifying Genes and Proteins Affecting Graves Disease

Target-Based Drug Discovery Begins with Understanding Disease Pathophysiology image 0
Figure 1: Network view showing genes which may mediate the effect of PTX3 in Graves’ disease.

TLR4 as a Potential Mediator of PTX3 in Graves’ Disease

Conclusion

References

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